Opportunity Information: Apply for PA 18 651
The National Institutes of Health (NIH) funding opportunity PA 18 651, titled "Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults (R01 Clinical Trial Optional)," supports research that improves HIV prevention and HIV treatment outcomes for adolescents and emerging adults by explicitly grounding studies in what is known about development during these life stages. The central idea is that adolescents and young adults are not a single, uniform group, and HIV risks, engagement in prevention, testing behaviors, linkage to care, adherence, and long-term retention can look very different depending on developmental maturity, social context, family dynamics, school or work transitions, identity development, and changing peer and relationship influences. NIH is looking for projects that use modern adolescent and young adult developmental science to design and test approaches that are better matched to the realities of this age range, rather than simply adapting adult-oriented strategies.
This announcement encourages research across the HIV continuum, including prevention and care, with an emphasis on developmentally appropriate methods and outcomes. In practice, that can include studies that refine how prevention tools are delivered and supported (for example, uptake and persistence with PrEP, adherence supports tailored to shifting routines, or approaches that fit the needs of youth navigating disclosure and stigma). It also includes research aimed at improving testing, linkage to care after diagnosis, initiation of antiretroviral therapy, medication adherence, viral suppression, and retention in care for youth living with HIV. Because the FOA highlights the heterogeneity of adolescents and emerging adults, strong applications will generally show a clear rationale for the age range selected, explain why developmental stage matters for the barriers and facilitators being studied, and propose measures and designs that can capture change over time as youth mature and their environments change.
The mechanism referenced in the title is the R01, with clinical trials allowed but not required ("Clinical Trial Optional"). An R01 is typically used for a more substantial, fully powered research project, often supported by preliminary data and a well-developed plan that may include longitudinal follow-up or multi-component analyses. The notice also points applicants to parallel opportunities using different NIH mechanisms: an R21 for high-risk/high-reward exploratory work that may not have extensive preliminary data (including projects that primarily analyze existing data), and an R34 for teams that want to develop an intervention and complete early-stage pilot testing to prepare for a larger efficacy or effectiveness trial. In other words, NIH is trying to match the size and maturity of the project to the right grant pathway: exploratory concepts to R21, intervention development and pilot work to R34, and more definitive or longitudinal studies to R01.
Eligibility is broad and includes many types of applicants beyond traditional research universities. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status; for-profit organizations (including small businesses); and other organizations. The FOA also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This wide eligibility signals an interest in reaching communities and institutions that are closely connected to youth populations most affected by HIV, including settings where culturally grounded, community-engaged research may be especially important.
From an administrative standpoint, this is a discretionary grant program under NIH, categorized under Education and Health, with CFDA (now Assistance Listing) numbers 93.242, 93.279, 93.307, and 93.855. The opportunity was created on February 12, 2018, and the source data lists an original closing date of January 7, 2021. The award ceiling and expected number of awards are not specified in the provided listing, which is common for NIH announcements where budgets are primarily driven by project scope, allowable costs, and institute-specific funding decisions.
Overall, the opportunity is aimed at improving HIV-related outcomes for adolescents and young adults by funding research that takes development seriously, uses age-appropriate endpoints and strategies, and produces evidence that can lead to more effective prevention and care models for youth as they move through adolescence into emerging adulthood.Apply for PA 18 651
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.279, 93.307, 93.855.
- This funding opportunity was created on 2018-02-12.
- Applicants must submit their applications by 2021-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: NIH PA 18 651 - Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults (R01 Clinical Trial Optional)
What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity announcement (FOA) identified as PA 18 651. It supports research designed to improve HIV prevention and HIV treatment outcomes for adolescents and emerging adults by explicitly grounding the work in modern developmental science for these life stages.
What is the main goal of PA 18 651?
The goal is to fund research that improves outcomes across the HIV prevention and care continuum for adolescents and young adults by using approaches that are developmentally tailored, rather than simply adapting strategies designed for adults.
Who is the focus population for this FOA?
The focus is on adolescents and emerging adults (often described as adolescents and young adults). The FOA emphasizes that this group is not uniform and that HIV-related risks and care behaviors can vary widely depending on developmental maturity and life context.
Why does the FOA emphasize developmental tailoring?
Because adolescents and young adults can differ substantially in how they experience risk, how they engage with prevention and testing, and how they initiate and stay in care. Developmental stage, social context, family dynamics, school or work transitions, identity development, and peer and relationship influences can shape barriers and facilitators in ways that are different from adults.
What parts of the HIV continuum does this FOA support?
The FOA encourages research across the HIV continuum, including prevention and care. That includes prevention engagement, testing behaviors, linkage to care after diagnosis, initiation of antiretroviral therapy, medication adherence, viral suppression, and long-term retention in care for youth living with HIV.
What are examples of prevention topics that fit this announcement?
Examples described include refining how prevention tools are delivered and supported for youth, such as uptake and persistence with PrEP, adherence supports tailored to shifting routines, and approaches that fit the needs of youth navigating disclosure and stigma.
What are examples of care topics that fit this announcement?
Examples described include improving linkage to care after diagnosis, initiation of antiretroviral therapy, medication adherence, viral suppression, and retention in care among adolescents and young adults living with HIV.
Does NIH expect applicants to treat adolescents and young adults as one group?
No. A central theme of the FOA is heterogeneity: adolescents and young adults are not a single, uniform population. Strong applications generally explain why the chosen age range makes sense and why developmental stage is important for the barriers and facilitators being studied.
What does "developmentally appropriate methods and outcomes" mean in this FOA?
In this context, it means designing research methods, measures, and outcomes that fit the realities of adolescence and emerging adulthood and can capture how needs, behaviors, and environments change over time as youth mature.
Does the FOA encourage longitudinal or change-over-time designs?
Yes. The FOA notes that strong applications often propose measures and designs that can capture change over time as youth mature and as their environments change.
What grant mechanism is used for PA 18 651?
The mechanism referenced is the NIH R01.
Are clinical trials required under this R01?
No. The FOA is labeled "Clinical Trial Optional," meaning clinical trials are allowed but not required.
What kind of project is an R01 typically used for?
Based on the FOA description, an R01 is typically used for a more substantial, fully powered research project, often supported by preliminary data and a well-developed plan. It may include longitudinal follow-up or multi-component analyses.
Are there related NIH opportunities mentioned for other project stages?
Yes. The FOA points to parallel opportunities using other NIH mechanisms: an R21 and an R34.
How does the R21 differ from the R01 in the context described?
The R21 is described as supporting high-risk/high-reward exploratory work that may not have extensive preliminary data, including projects that primarily analyze existing data.
How does the R34 differ from the R01 in the context described?
The R34 is described as supporting teams that want to develop an intervention and complete early-stage pilot testing to prepare for a larger efficacy or effectiveness trial.
How should an applicant decide between R21, R34, and R01 based on the description provided?
The FOA framing suggests matching the maturity of the work to the pathway: exploratory concepts to R21, intervention development and pilot work to R34, and more definitive or longitudinal studies to R01.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include various government entities (state, county, city or township, special district), independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses), and other organizations.
Does the FOA explicitly include community-based or faith-based organizations?
Yes. The listing explicitly calls out faith-based or community-based organizations among additional eligible applicant categories.
Are minority-serving institutions and historically underrepresented institutions included in eligibility?
Yes. The FOA explicitly calls out categories such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, and Tribally Controlled Colleges and Universities.
Are U.S. territories included as eligible applicants?
Yes. The FOA explicitly includes U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations).
Are federal agencies eligible to apply?
Yes. The FOA lists eligible federal agencies among the additional eligible applicant categories.
What is the program type and category?
It is described as a discretionary grant program under NIH, categorized under Education and Health.
What Assistance Listing (CFDA) numbers are associated with this opportunity?
The listing includes CFDA (now Assistance Listing) numbers 93.242, 93.279, 93.307, and 93.855.
When was this opportunity created?
The source information states the opportunity was created on February 12, 2018.
What is the closing date shown in the provided listing?
The source data lists an original closing date of January 7, 2021.
Is the award ceiling specified?
No. The provided listing does not specify an award ceiling.
Is the expected number of awards specified?
No. The provided listing does not specify the expected number of awards.
Why might budget limits and number of awards be unspecified for this NIH announcement?
The listing notes this is common for NIH announcements where budgets are primarily driven by project scope, allowable costs, and institute-specific funding decisions.
What makes an application "strong" according to the themes described?
Based on the description, strong applications typically (1) provide a clear rationale for the chosen age range, (2) explain why developmental stage matters for the barriers and facilitators being studied, and (3) propose measures and designs that can capture change over time as youth mature and contexts shift.
Is this FOA limited only to prevention research?
No. The FOA encourages research across prevention and care, including testing, linkage, treatment initiation, adherence, viral suppression, and retention.
Is the FOA limited only to care research for youth living with HIV?
No. The FOA includes both prevention-focused research and care-focused research, covering outcomes for youth at risk for HIV as well as youth living with HIV.
What is the overall purpose of funding this line of research?
The overall purpose is to produce evidence that leads to more effective, developmentally appropriate HIV prevention and care models for adolescents and young adults as they move through adolescence into emerging adulthood.
Browse more opportunities from the same category: Education, Health
Next opportunity: Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76 Independent Clinical Trial Required)
Previous opportunity: Awards for Faculty
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 18 651
Applicants also applied for:
Applicants who have applied for this opportunity (PA 18 651) also looked into and applied for these:
| Funding Opportunity |
|---|
| Developmentally Tailored HIV Prevention and Care Research for Adolescents and Young Adults (R21 Clinical Trial Not Allowed) Apply for PA 18 652 Funding Number: PA 18 652 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Basic Research in Cancer Health Disparities (R21 Clinical Trial Not Allowed) Apply for PAR 18 655 Funding Number: PAR 18 655 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Basic Research in Cancer Health Disparities (R01 Clinical Trials Not Allowed) Apply for PAR 18 654 Funding Number: PAR 18 654 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploiting Omics Assays to Investigate Molecular Regulation of Persistent HIV in Individuals with Substance Use Disorder (R61/R33 Clinical Trial Optional) Apply for RFA DA 19 003 Funding Number: RFA DA 19 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R01 Clinical Trial Optional) Apply for PAR 18 675 Funding Number: PAR 18 675 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| U.S. Tobacco Control Policies to Reduce Health Disparities (R21 Clinical Trial Optional) Apply for PAR 18 674 Funding Number: PAR 18 674 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R21 - Clinical Trial Not Allowed) Apply for PA 18 678 Funding Number: PA 18 678 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Epidemiologic Research on Emerging Risk Factors and Liver Cancer Susceptibility (R01 - Clinical Trial Not Allowed) Apply for PA 18 677 Funding Number: PA 18 677 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (R01 Clinical Trial Optional) Apply for PAR 18 681 Funding Number: PAR 18 681 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Short-term Mentored Career Enhancement Awards for Mid-Career Investigators to Integrate Basic Behavioral and Social Sciences (K18 Clinical Trial Required) Apply for PAR 18 692 Funding Number: PAR 18 692 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Science-Based Quality Measurement and Management Development for Opioid Use Disorder Treatment (R61/R33 Clinical Trial Required) Apply for RFA DA 19 005 Funding Number: RFA DA 19 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed) Apply for PA 18 705 Funding Number: PA 18 705 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research Answers to National Cancer Institute's (NCI) Provocative Questions (R01 Clinical Trial Optional) Apply for RFA CA 18 019 Funding Number: RFA CA 18 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Research Answers to National Cancer Institute's (NCI) Provocative Questions (R21 Clinical Trial Optional) Apply for RFA CA 18 020 Funding Number: RFA CA 18 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01, Clinical Trial Optional) Apply for RFA DA 18 022 Funding Number: RFA DA 18 022 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Coordinating Center to Support NIDA Rural Opioid HIV and Comorbidity Initiative (U24 - Clinical Trial Not Allowed) Apply for RFA DA 19 004 Funding Number: RFA DA 19 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43 Clinical Trial Optional) Apply for PAR 18 717 Funding Number: PAR 18 717 Agency: National Institutes of Health Category: Education, Health Funding Amount: $280,000 |
| Workshop on the Use of Adolescent Brain Cognitive Development (ABCD) Data (R25 Clinical Trial Not Allowed) Apply for RFA DA 19 006 Funding Number: RFA DA 19 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R21 Clinical Trial Optional) Apply for PA 18 723 Funding Number: PA 18 723 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Improving Patient Adherence to Treatment and Prevention Regimens to Promote Health (R01 Clinical Trial Optional) Apply for PA 18 722 Funding Number: PA 18 722 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 18 651", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.