Opportunity Information: Apply for PA 16 452
The Kidney Precision Medicine Project (KPMP) - Technology Development and Validation (R43/R44) funding opportunity (PA 16-452) is a National Institutes of Health (NIH) small business grant program designed to accelerate practical, high-impact technologies that support the KPMP research effort. KPMP is a major initiative focused on improving how kidney disease is understood and treated by using human kidney biopsy tissue from people with acute kidney injury (AKI) and chronic kidney disease (CKD). By collecting and deeply analyzing these biopsies, KPMP aims to build a detailed kidney tissue atlas, sort patients into biologically meaningful disease subgroups, and pinpoint the specific cells, molecular pathways, and therapeutic targets that drive different forms of kidney injury and chronic damage.
The core purpose of this FOA is technology-focused: it invites small businesses to create and validate tools that either (1) make human kidney biopsy safer and more effective to obtain, or (2) significantly enhance how biopsy tissue is analyzed so that each biopsy yields reliable and useful research or clinical information. In practice, this means the NIH is looking for technologies that reduce biopsy risk, improve sampling consistency, preserve tissue quality, increase the amount of information that can be extracted from limited biopsy material, and strengthen confidence in the resulting datasets. The emphasis on development and validation signals that proposals should move beyond basic ideas and instead demonstrate a clear path toward a working, tested product or platform that can be adopted within KPMP-style workflows.
This opportunity uses the SBIR funding mechanism (R43/R44), which is structured to support small business innovation from early feasibility through later-stage development. In broad terms, the R43 phase typically supports initial proof-of-concept and early technical validation, while the R44 phase supports more advanced development, refinement, and steps toward commercialization or broader deployment. The underlying expectation is that awardees will produce a technology that is not only scientifically sound but also usable in real-world settings where human kidney biopsy tissue is collected, processed, measured, and interpreted.
Eligibility is limited to small businesses. Non-U.S. entities (foreign institutions) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. However, certain foreign components, as NIH defines them in the NIH Grants Policy Statement, may be permitted in some cases, meaning a U.S. small business might be able to include limited foreign collaboration or activities if they meet NIH policy requirements and are appropriately justified. The sponsoring agency is the NIH, the opportunity is categorized as discretionary funding, and it is listed under CFDA 93.847. The original closing date in the source information is 2020-01-05, and the record shows no specified award ceiling or expected number of awards in the provided fields.
Overall, the opportunity is best read as a targeted call for small businesses to solve concrete bottlenecks in kidney biopsy acquisition and tissue interrogation that could slow down or limit the KPMP mission. Successful projects would be expected to strengthen the quality, safety, and interpretability of human kidney biopsy data, enabling the creation of a robust kidney tissue atlas and helping the research community move toward more precise, mechanism-based diagnosis and treatment of AKI and CKD.Apply for PA 16 452
- The National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "Kidney Precision Medicine Project - Technology Development and Validation (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on 2016-09-28.
- Applicants must submit their applications by 2020-01-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 16 452) also looked into and applied for these:
| Funding Opportunity |
|---|
| Kidney Precision Medicine Project - Technology Development and Validation (R41/R42) Apply for PA 16 451 Funding Number: PA 16 451 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Addressing Health Disparities in NIDDK Diseases (R01) Apply for PA 17 021 Funding Number: PA 17 021 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Circadian Mechanisms Contributing to Obesity, Diabetes Metabolism, and Underlying Heart, Lung, and Blood Disorders (R01) Apply for RFA HL 17 020 Funding Number: RFA HL 17 020 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| NIDDK Exploratory Clinical Trials for Small Business (R44) Apply for PAR 17 034 Funding Number: PAR 17 034 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pilot Clinical Trials in Pediatric Chronic Kidney Disease Data Coordinating Center (U24) Apply for RFA DK 16 035 Funding Number: RFA DK 16 035 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Pilot Clinical Trials in Pediatric Chronic Kidney Disease Participating Clinical Centers (U01) Apply for RFA DK 16 018 Funding Number: RFA DK 16 018 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Centers (Collaborative U01) Apply for RFA DK 16 025 Funding Number: RFA DK 16 025 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $200,000 |
| Limited Competition: Research Resource for Human Organs and Tissues (U42) Apply for RFA OD 17 001 Funding Number: RFA OD 17 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Limited Competition: Continuation of the Preventing Early Renal Loss in Diabetes (PERL) Study (UC4) Apply for RFA DK 16 506 Funding Number: RFA DK 16 506 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Silvio O. Conte Digestive Diseases Research Core Centers (P30) Apply for RFA DK 17 001 Funding Number: RFA DK 17 001 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $750,000 |
| Therapeutic Targeting Of The Human Islet Environment (UC4) Apply for RFA DK 17 003 Funding Number: RFA DK 17 003 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $600,000 |
| Competitive Collaborative Projects for Human Islet Biology (UC4) Apply for RFA DK 17 004 Funding Number: RFA DK 17 004 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $350,000 |
| Limited Competition: Follow-up on Subjects and Immunological Assessments in The Environmental Determinants of Diabetes In The Young Study (TEDDY) (UC4) Apply for RFA DK 16 504 Funding Number: RFA DK 16 504 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Biomarkers for Diabetes, Digestive, Kidney and Urologic Diseases Using Biosamples from the NIDDK Repository (R01) Apply for PAR 17 123 Funding Number: PAR 17 123 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $250,000 |
| Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R41/R42) Apply for PA 17 131 Funding Number: PA 17 131 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R43/R44) Apply for PA 17 130 Funding Number: PA 17 130 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R18) Apply for PAR 17 177 Funding Number: PAR 17 177 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: Case Dependent |
| Evaluating Natural Experiments in Healthcare to Improve Diabetes Prevention and Treatment (R18) Apply for PAR 17 178 Funding Number: PAR 17 178 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $500,000 |
| Planning Grants for Pragmatic Research in Healthcare Settings to Improve Diabetes and Obesity Prevention and Care (R34) Apply for PAR 17 180 Funding Number: PAR 17 180 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $150,000 |
| Pragmatic Research in Healthcare Settings to improve Kidney Disease Prevention and Care (R18) Apply for RFA DK 17 008 Funding Number: RFA DK 17 008 Agency: National Institutes of Health Category: Food and Nutrition, Health Funding Amount: $325,000 |
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