Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U24 Clinical Trial Not Allowed) | RFA DA 25 038

Opportunity Information: Apply for RFA DA 25 038

The National Institutes of Health (NIH), through the National Institute on Drug Abuse (NIDA), is soliciting applications under the funding opportunity titled "Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U24 Clinical Trial Not Allowed)." This is a discretionary funding opportunity that uses a cooperative agreement mechanism (U24), which generally means the awardee will work in close partnership with NIH/NIDA staff and other consortium members, with substantial programmatic involvement from the agency. The goal of the opportunity is to establish and operate a Data Coordination Center (DCC) for the TranSINDA Consortium, which focuses on understanding how social and environmental factors shape neurocognitive development and, ultimately, influence risk for substance use and addiction.

At the center of this NOFO is the creation of an organizational and technical hub that can handle the full life cycle of consortium data. The DCC is expected to manage, curate, and enable broad sharing of TranSINDA data, while also building what the NOFO describes as a "modern data ecosystem." In practical terms, this means putting in place infrastructure that does more than store files. The DCC is meant to integrate the consortiums data repository under common data standards so that information collected across sites, studies, or modalities can be combined, compared, and reused without excessive reformatting or bespoke processing each time a new analysis is needed.

A major emphasis is on making the data actively usable at scale. The DCC is expected to serve as a resource for software tools that support large-scale data querying, analysis, visualization, and integration. That points to capabilities like searchable datasets, standardized metadata, interoperable formats, and tools that make it realistic for researchers to find the right data, understand it, and analyze it efficiently. Visualization and integration language also signals an interest in supporting cross-domain work, for example linking socioenvironmental measures with neurocognitive outcomes or other relevant scientific data types, in ways that can be explored and tested by consortium teams and, where permitted, the broader research community.

Beyond technical infrastructure, the DCC is also responsible for consortium coordination functions. This includes facilitating collaboration across TranSINDA participants and supporting the operational needs that keep a multi-site, multi-team program running smoothly, such as coordination of timelines, reporting, meetings, documentation, and shared workflows. The DCC is also tasked with addressing policy issues related to data sharing and data use. That typically involves governance practices around access, privacy, consent limitations, documentation of permissible use, and ensuring that sharing aligns with NIH expectations and any legal or ethical requirements tied to human data. Even though the NOFO is labeled "Clinical Trial Not Allowed," data governance still matters because many consortium datasets may involve human participants and sensitive socioenvironmental or developmental information.

The opportunity is identified by Funding Opportunity Number RFA-DA-25-038, and it is categorized under education and health with CFDA number 93.279. The original application closing date listed is 2024-12-03, with a creation date of 2024-07-18. While the listing shows the award ceiling and expected number of awards as not specified in the provided source text, applicants would typically look to the full NOFO for budget guidance, project period expectations, and review criteria.

Eligibility is broad and includes many standard applicant types: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other entities. The NOFO also explicitly notes additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). Taken together, this indicates NIH is open to a wide range of organizations that can credibly operate a sophisticated coordinating center with strong data management, informatics, and consortium leadership capacity.

In essence, this NOFO is not asking applicants to run an intervention study or a clinical trial. It is asking applicants to build and operate the backbone of a research consortium: a DCC that can standardize and integrate complex data, provide tools and platforms that make the data findable and usable, and handle the coordination and policy framework that allows the TranSINDA Consortium to function efficiently and to share data responsibly.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Translating Socioenvironmental Influences on Neurocognitive Development and Addiction Risk (TranSINDA) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
• This funding opportunity was created on 2024-07-18.
• Applicants must submit their applications by 2024-12-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DA 25 038

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: